This program focuses on identifying critical research facilities renovations, alterations, repairs, and other facilities improvements that will specifically catalyze broad-based future research opportunities. This includes, but is not limited to, requests for needed improvements to (1) meet anticipated research growth; (2) catalyze future research in strategic areas of focus; (3) build core or center capacity; (4) provide for facility maintenance (e.g., mechanical and electrical improvements for research labs currently hindered by the spatial environment); (5) renovate facilities to meet needs for new equipment installations; or (6) meet future regulatory requirements. Funding for this program is one-time monies for direct infrastructural facilities improvement or renovation needs only. The proposal should focus on direct research support, as oppose to administrative support for research.  Equipment purchases are not allowed under this RFP.