Explore ARC’s Metabolomics, Proteomics and Ionomics Services
Advance your research with comprehensive metabolomics, proteomics, and ionomics services supported by cutting‑edge mass spectrometry platforms and expert analytical guidance. From experimental design to data interpretation, the ARC Bioanalysis & Omics team delivers customized workflows to uncover deep insights into complex biological systems.
Metabolomics
Our metabolomics services support targeted and untargeted analysis of all small molecules, volatile analytes, hormones, central carbon and nitrogen metabolites, natural products, and lipids (lipidomics). Services include everything from experimental design guidance, sample preparation, data acquisition, and data analysis.
Services:
- Sample preparation.
- Small molecule quantification.
- Targeted metabolomics panels include phytohormone analysis, short chain fatty acids (SCFA), steroid hormones, oxylipins, and Biocrates-based metabolomics kits, among many others. Custom assays also available.
- Untargeted metabolomics can be performed using liquid or gas chromatography.
- Full data processing, annotation, statistical analysis, using latest software.
- Reporting including full methods details, quality control metrics, and results.
Instruments:
- Waters Xevo G2-XS Q-TOF coupled to Acquity UPLC via ESI ionization source.
- Waters Synapt G2-Si Ion Mobility enabled Q-TOF coupled to Acquity UPLC via ESI ionization source
- Agilent 5890 GC coupled to Xevo G2 QTOF via APGC ionization source
- Thermo Trace 1310 GC coupled with ISQ single quadruple MS with liquid autosampler
- Thermo Trace 1310 GC couple with ISQ single quadruple MS with headspace autosampler and olfactory detector
- Waters Xevo G2 TQS triple quadrupole MS coupled with UPLC or nanoUPLC
Proteomics
Our Proteomics services include simple protein identification, molecular weight determination, and full untargeted quantitative proteomics experiments identifying hundreds to thousands of proteins. We have been actively honing method to support Metaproteomics (proteomes from microbiomes) as well.
Services:
- Protein identification via digestion and LC-MS/MS
- Comprehensive untargeted bottom-up proteomics, optionally including PTM searching, TMT labelling, etc.
- Intact protein analysis, with mass accuracy < 100 PPM mass error
- Targeted peptide/proteome analysis.
- Sample preparation
- Data-dependent MS/MS (DDA) or data-independent MS/MS (DIA)
- Data analysis includes quality control reporting, protein/peptide identification, quantification, and annotation, and basic statistical analysis.
- Reporting including full methods details, quality control metrics, and results.
Instruments:
- Thermo Scientific Orbitrap Eclipse with FAIMS and Vanquish II UHPLC
- Waters Synapt G2-Si Ion Mobility enabled Q-TOF coupled to Acquity UPLC via ESI ionization source
- Waters Xevo G2-XS Q-TOF coupled to Acquity UPLC via ESI ionization source.
Ionomics
Ionomics approaches provide relative or absolute quantifications of the inorganic components of biological samples using ICP-MS. We operate a Perkin Elmer Nexion system to support ionomics and metals-analysis needs.
Services:
- A full panel of elements can be acquired using the Perkin Elmer ‘TotalQuant’ approach
- Sensitive and quantitative targeted analysis of metals including lead, arsenic, and other inorganic analyses.
- Sample preparation using either open vessel and microwave digestion,
- Reporting including full methods details, quality control metrics, and results.
Instruments:
- NexION 350D mass spectrometer (PerkinElmer,) with prepFAST SC-2 (Elemental Scientific) autosampler
Custom Assays
We offer a diverse range of targeted assays, supported by state-of-the-art instrumentation and decades of analytical expertise. We are continually expanding our assay offerings and welcome inquiries about new or custom assays.
For a full list of existing assays, visit our assay directory. If you’re looking for a specific assay not listed, please contact us—we’re always eager to explore new possibilities.