{"id":61,"date":"2025-12-03T00:09:24","date_gmt":"2025-12-03T00:09:24","guid":{"rendered":"https:\/\/www.research.colostate.edu\/orcc\/clinical-review-board\/resources\/"},"modified":"2026-02-06T19:05:21","modified_gmt":"2026-02-06T19:05:21","slug":"resources","status":"publish","type":"page","link":"https:\/\/www.research.colostate.edu\/orcc\/clinical-review-board\/resources\/","title":{"rendered":"Resources"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Statistics &amp; Sample Size Calculations<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.research.colostate.edu\/orcc\/wp-content\/uploads\/sites\/24\/2025\/12\/EpiZ_March_2014-1.xlsx\">Sample Size to Detect Presence or Absence of Disease<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.research.colostate.edu\/orcc\/wp-content\/uploads\/sites\/24\/2025\/12\/Statistic-for-vets-1.docx\">Statistics for Vets<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.research.colostate.edu\/orcc\/wp-content\/uploads\/sites\/24\/2025\/12\/Samplesize-determination-1.doc\">Sample Size Determination<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.openepi.com\/Menu\/OE_Menu.htm\">Open Source Epidemiologic Statistics for Public Health*<\/a><\/div>\n<\/div>\n\n\n\n<p class=\"has-small-font-size\"><em>*for&nbsp;sample size calculation and simple statistical analysis<\/em><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Clinical Trials Registries<\/h2>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>CSU Veterinary Teaching Hospital Clinical Trials Webpage<\/summary>\n<p><a href=\"https:\/\/vetmedbiosci.colostate.edu\/vth\/clinical-trials\/\">Ongoing clinical trials at the CSU VTH&nbsp;<\/a><\/p>\n\n\n\n<p>CSU investigators can<a href=\"https:\/\/colostate.sharepoint.com\/sites\/CVMBS-ClinSci\/_layouts\/15\/AccessDenied.aspx?Source=https%3A%2F%2Fcolostate%2Esharepoint%2Ecom%2Fsites%2FCVMBS%2DClinSci%2FSitePages%2FClinical%2DSciences%2DResearch%2Easpx&amp;correlation=599cd99f%2Db08b%2D0000%2Dc3f1%2D492e1ccf7d64&amp;Type=item&amp;name=b80e7689%2Dc2ef%2D4088%2Dadf8%2D5233276fc2c7&amp;listItemId=20\">&nbsp;add their clinical<\/a>&nbsp;trials to the webpage&nbsp;<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>AVMA Veterinary Clinical Trials Registry<\/summary>\n<p><a href=\"https:\/\/veterinaryclinicaltrials.org\/\">The AVMA Veterinary Clinical Trials Registry<\/a>\u2014formerly the AVMA Animal Health Studies Database\u2014helps animal owners and veterinarians find veterinary clinical studies in the U.S. and Canada for their pets and patients. The AVMA is proud to provide this registry to help advance the practice of veterinary medicine and accelerate improvements in animal health care.<\/p>\n\n\n\n<p><strong>Registry Highlights:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Febusiness.avma.org%2Flogin.aspx&amp;data=05%7C02%7Ctracy.webb%40colostate.edu%7C923723402ae84caf1b9008dc2c9dbd6c%7Cafb58802ff7a4bb1ab21367ff2ecfc8b%7C0%7C0%7C638434303217558428%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=ZOFyA6lSYT%2F3R%2BnTAZdmwrxzcOisG0L1XlKemUsI0N8%3D&amp;reserved=0\">Sign in<\/a> to the new registry with your usual credentials<\/li>\n\n\n\n<li>Access previously submitted studies&nbsp;<\/li>\n\n\n\n<li>Make edits to ongoing studies<\/li>\n\n\n\n<li>Submit new studies<\/li>\n\n\n\n<li>Manage interested participants<\/li>\n\n\n\n<li>Enter results when studies conclude<\/li>\n\n\n\n<li>Search studies with a variety of criteria and filters<\/li>\n<\/ol>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>FDA List of Clinical Field Studies of Animal Cells, Tissues, and Cell- and Tissue-Based Products<\/summary>\n<p>The U.S. Food and Drug Administration maintains a listing of clinical field studies that investigate Animal Cells, Tissues, and Cell- and Tissue-Based Products (ACTPs) in veterinary patients. The&nbsp;<a href=\"https:\/\/www.fda.gov\/animal-veterinary\/cell-and-tissue-products-animals\/clinical-field-studies-animal-cells-tissues-and-cell-and-tissue-based-products-actps\" target=\"_blank\" rel=\"noreferrer noopener\">webpage&nbsp;<\/a>provides animal owners, veterinarians, researchers, and the public with information on clinical&nbsp;field&nbsp;studies&nbsp;that are being investigated for the use of ACTPs in veterinary patients. Sponsors of ACTPs that are interested in having their clinical trials listed on the&nbsp;FDA\u2019s webpage can&nbsp;contact&nbsp;<a href=\"mailto:CVM_PM_Biotech@fda.hhs.gov\">their FDA project manager<\/a><\/p>\n<\/details>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Study Design &amp; Reporting<\/h2>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>&nbsp;Consolidated Standards of Reporting Trials [CONSORT]&nbsp;<\/summary>\n<ol class=\"wp-block-list\">\n<li><a href=\"http:\/\/www.consort-statement.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Consolidated Standards of Reporting Trials [CONSORT]<\/a>&nbsp;The website contains helpful information about abstracts, cluster designs, reporting of harms, herbal interventions, non-inferiority and equivalence studies, trials of non-pharmacologic interventions, and pragmatic trials.\n<ul class=\"wp-block-list\">\n<li><a href=\"http:\/\/www.consort-statement.org\/consort-2010\" target=\"_blank\" rel=\"noreferrer noopener\">CONSORT Statement<\/a>: an evidence-based, minimum set of recommendations for reporting randomized trials, including a 25-item&nbsp;<a href=\"http:\/\/www.consort-statement.org\/consort-statement\/checklist\" target=\"_blank\" rel=\"noreferrer noopener\">checklist<\/a>&nbsp;and a&nbsp;<a href=\"http:\/\/www.consort-statement.org\/consort-statement\/flow-diagram\" target=\"_blank\" rel=\"noreferrer noopener\">flow diagram<\/a>.<\/li>\n\n\n\n<li>CONSORT \u201cExplanation and Elaboration\u201d document: explains and illustrates the principles underlying the CONSORT Statement.<\/li>\n\n\n\n<li><a href=\"http:\/\/www.consort-statement.org\/extensions\" target=\"_blank\" rel=\"noreferrer noopener\">Extensions of the CONSORT Statement<\/a>: give additional guidance for randomized controlled trials (RCTs) with specific designs, data, and interventions.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>&nbsp;MOOSE: Meta-analysis of Observational Studies in Epidemiology: A Proposal for Reporting.&nbsp;<\/summary>\n<p><a href=\"http:\/\/jama.ama-assn.org\/cgi\/reprint\/283\/15\/2008\" target=\"_blank\" rel=\"noreferrer noopener\">MOOSE: Meta-analysis of Observational Studies in Epidemiology: A Proposal for Reporting.&nbsp;<\/a>Donna F. Stroup, et al. published in J Am Med Assoc 2000; 283:2008-2012.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA].<\/summary>\n<p><a href=\"http:\/\/prisma-statement.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA]<\/a>. Per the website, \u201cPRISMA is an evidence-based minimum set of items for&nbsp;<em>reporting in systematic reviews and meta-analyses<\/em>\u201d and \u201cfocuses on the reporting of&nbsp;<em>reviews evaluating randomized trials\u2026.<\/em>\u201c<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>Reporting guidelines for randomized controlled trials for Livestock and food safety [REFLECT].&nbsp;<\/summary>\n<p><a href=\"http:\/\/reflect-statement.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Reporting Guidelines for Randomized Controlled Trials for Livestock and Food Safety [REFLECT]<\/a>.&nbsp; Per the website, REFLECT provides \u201cevidence-based minimum set of items for&nbsp;<em>trials reporting production, health, and food-safety outcomes.<\/em>\u201c<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>&nbsp;&nbsp;STARD: Standards for reporting of diagnostic accuracy studies<\/summary>\n<p><a href=\"http:\/\/www.stard-statement.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">STARD<\/a>: The objective of the STARD initiative is to improve the accuracy and completeness of reporting&nbsp;<em>studies of diagnostic accuracy<\/em>, to allow readers to assess the potential for bias in the study, and to evaluate its generalisability.&nbsp; Several papers have been published with checklists and flow charts:<\/p>\n\n\n\n<p><a href=\"https:\/\/www.thelancet.com\/pb-assets\/Lancet\/extras\/02cor11089web.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Bossuyt PM, et al. 2003. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative.&nbsp;<em>The Lancet<\/em>. Vol 361.<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.bmj.com\/content\/351\/bmj.h5527\" target=\"_blank\" rel=\"noreferrer noopener\">Bossuyt PM, et al. 2015. An updated list of essential items for reporting diagnostic &nbsp;&nbsp; accuracy studies.&nbsp;<em>BMJ<\/em>. 351:5527.<\/a><\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>&nbsp;Strengthening the Reporting of Observational Studies in Epidemiology [STROBE]<\/summary>\n<p><a href=\"http:\/\/www.strobe-statement.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Strengthening the Reporting of Observational studies in Epidemiology [STROBE]<\/a>:&nbsp; An international, collaborative initiative of epidemiologists, methodologists, statisticians, researchers, and journal editors involved in the conduct and dissemination of observational studies\u2026.&nbsp; The website includes checklists, publications, a discussion forum, as well as other information.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>Veterinary Oncology Clinical Trials<\/summary>\n<p>Thamm DH, Vail DM.&nbsp; Veterinary oncology clinical trials: design and implementation. &nbsp;&nbsp; 2015.&nbsp;<em>Vet J<\/em>.<\/p>\n\n\n\n<p>Examples:<\/p>\n\n\n\n<p>London CA, et al. 2009. Multi-center, placebo-controlled, double-blind, randomized study of oral Toceranib Phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision.&nbsp;<em>Cancer Therapy: Clinical.<\/em><\/p>\n\n\n\n<p>Burton JH, et al. 2015. Pulse-administered Toceranib Phosphate plus Lomustine for treatment of unresectable mast cell tumors in dogs.&nbsp;<em>JVIM<\/em>.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-style-details-outline is-layout-flow wp-block-details-is-layout-flow\"><summary>PetSORT Standards of Reporting Trials in Pets Checklist<\/summary>\n<p>The standards of reporting trials in pets (PetSORT):&nbsp;<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2023.1137781\/full\">explanation and elaboration.<\/a><\/p>\n\n\n\n<p>This publication includes a checklist of information to include when reporting a randomized trial.<\/p>\n<\/details>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Statistics &amp; Sample Size Calculations *for&nbsp;sample size calculation and simple statistical analysis Clinical Trials Registries Study Design &amp; Reporting<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":54,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":true,"footnotes":""},"microsite":[8],"class_list":["post-61","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/pages\/61","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/comments?post=61"}],"version-history":[{"count":0,"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/pages\/61\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/pages\/54"}],"wp:attachment":[{"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/media?parent=61"}],"wp:term":[{"taxonomy":"microsite","embeddable":true,"href":"https:\/\/www.research.colostate.edu\/orcc\/wp-json\/wp\/v2\/microsite?post=61"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}